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L. Eric Huang

Professor
Department of Neurosurgery
Huntsman Cancer Institute
United States of America

Biography

Eric Huang, MD, PhD, is an Associate Professor in the Department of Neurosurgery and an adjunct Associate Professor in the Department of Oncological Sciences in the School of Medicine at the University of Utah. He is an investigator in the Huntsman Cancer Institute and a member of the Nuclear Control of Cell Growth and Differentiation program. Dr. Huang received his MD degree from the Shanghai Medical University, Shanghai, China in 1984. Following this he was a resident in Tumor Pathology at the Cancer Hospital-Shanghai Medical University in China between1984-1986. He then went on to complete his Ph.D. in 1994, in the area of cell and developmental biology from Rutgers University. Dr. Huang received postdoctoral training at the Brigham and Women’s Hospital, Harvard Medical School as a Research Fellow between 1994-1997. Following this, for approximately three years, Dr. Huang stayed on as an Instructor in Medicine at Harvard Medical School. In 2000 Dr. Huang became a Principal Investigator at the National Institute of Health in Bethesda, MD and Head of the Hypoxia and Tumorigenesis Unit in the Laboratory of Carcinogenesis, National Cancer Institute, National Institutes of Health. His research focuses on the study of the hypoxic environment (low oxygen tension), in which many cancer cells survive, and how hypoxia can make cancer more aggressive.

Research Interest

Brain Tumors Cancer Metabolism Disease Progression Epigenetics in Cancer Genetic Instability Hypoxia Isocitrate Dehydrogenase Mitochondria Mouse Models of Cancer Risk Factors

Publications

  • Yoo YG, Christensen J, Huang LE (2011). HIF-1{alpha} Confers Aggressive Malignant Traits on Human Tumor Cells Independent of Its Canonical Transcriptional Function. Cancer Res, 71(4), 1244-52.

  • Yoo YG, Christensen J, Gu J, Huang LE (2011). HIF-1{alpha} Mediates Tumor Hypoxia to Confer a Perpetual Mesenchymal Phenotype for Malignant Progression. Sci Signal, 4(178), pt4.

  • Hayashi M, Yoo YG, Christensen J, Huang LE (2011). Requirement of evading apoptosis for HIF-1alpha-induced malignant progression in mouse cells. Cell Cycle, 10(14), 2364-72.

  • Choi H, Gillespie DL, Berg S, Rice C, Couldwell S, Gu J, Colman H, Jensen RL, Huang LE (2015). Intermittent Induction of HIF-1alpha Produces Lasting Effects on Malignant Progression Independent of Its Continued Expression. PLoS One, 10(4), e0125125.

  • Huang LE, Cohen AL, Colman H, Jensen RL, Fults DW, Couldwell WT (2017). IGFBP2 expression predicts IDH-mutant glioma patient survival. Oncotarget, 8(1), 191-202.

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