Mahesh B. Chandrasekharan
Professor
Department of Radiation Oncology
Huntsman Cancer Institute
United States of America
Biography
Dr. Chandrasekharan received his PhD in 2001 from Texas A&M College Station, Texas in Biology. He stayed on as a Post Doctoral Research Associate in Dr. Timothy C. Hall's lab for another two years. He was a post doctoral fellow at Vanderbilt University in Nashville, TN in Dr. Zu-Wen Sun's lab until 2011. He is currently Research Assistant Professor in the Department of Radiation Oncology, Research Scholar at Huntsman Cancer Institute, and a member of the Nuclear Control of Cell Growth and Differentiation program.Dr. Chandrasekharan was awarded MS (Biotechnology) Merit Scholarship by the Department of Biotechnology by the Government of India in 1991 and Biology Doctoral Merit Award by the Department of Biology, Texas A&M University, College Station, TexasDr. Chandrasekharan’s research focus is to understand the regulation of function of histone modifications, which act as epigenetic mechanisms to regulate several aspects of organismal and cellular development, and which are frequently aberrant in cancer. He uses yeast as the primary model system of choice for his studies and intends to extend his findings to mammalian model systems. As a graduate student, he investigated how chromatin remodeling plays an important role in the spatial and temporal regulation of gene expression during plant development. His post-doctoral research was to understand the regulation and function of the evolutionarily-conserved crosstalk between histone H2B ubiquitination and histone H3 lysine 4 and lysine 79 (K4 and K79) methylation.
Research Interest
Histone Modifications Transcription Genome Stability
Publications
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Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW (2010). The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation. J Biol Chem, 285(32), 24548-61.
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Chandrasekharan MB, Huang F, Chen YC, Sun ZW (2010). Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination. Mol Cell Biol, 30(13), 3216-32.
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Chandrasekharan MB, Huang F, Sun ZW (2011). Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors. Methods, 54(3), 304-14.
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Joo HY, Jones A, Yang C, Zhai L, Smith AD 4th, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H (2011). Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J Biol Chem, 286(9), 7190-201.
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Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB (2013). Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression. Epigenetics Chromatin, 6(1), 27.
