Trudy G. Oliver
Professor
Department of Oncological Sciences
Huntsman Cancer Institute
United States of America
Biography
Dr. Oliver is an Assistant Professor in the Department of Oncological Sciences at the University of Utah and an Investigator at Huntsman Cancer Institute. She is also a member of the Cell Response and Regulation program. Dr. Oliver's research is devoted to understanding the mechanisms of cancer biology. As a graduate student in the lab of Rob Wechsler-Reya at Duke, she studied the developmental origins of the childhood brain tumor, medulloblastoma, where she identified mechanisms of tumor progression in mouse models of the disease. As an independent investigator, she uses mouse models of cancer and cell culture systems to study mechanisms of therapeutic resistance in lung cancer. Her experimental approaches include an integration of mouse genetics, molecular and cellular biology, biochemistry, genomics and in vivo imaging. This work will contribute to our understanding of therapeutic resistance mechanisms with the goal of identifying novel targets to thwart drug-resistant disease.
Research Interest
Lung Cancer Mouse Models of Cancer Neuroendocrine Tumors Mechanisms of Chemotherapy Resistance Cell Differentiation Oncogene and Tumor Suppressor Function Drug Screening Assays, Antitumor Drug Combinations Cisplatin Genes, p53
Publications
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Cowley DO, Rivera-Perez JA, Schliekelman M, He YJ, Oliver TG, Lu L, OQuinn R, Salmon ED, Magnuson T, Van Dyke T (2009). Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol, 29(4), 1059-71.
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Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T (2011). Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell, 43(1), 57-71.
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Terry MR, Arya R, Mukhopadhyay A, Berrett KC, Clair PM, Witt B, Salama ME, Bhutkar A, Oliver TG (2015). Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo. Cell Death Differ, 22(5), 719-30.
