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Basil G Hanss

ASSOCIATE PROFESSOR
Medicine, Nephrology, Medical Education and Pharmacological
Icahn School of Medicine at Mount Sinai
United States of America

Biography

Dr. Hanss is an Associate Professor at Mt. Sinai School of Medicine with appointments in the Departments of Medicine, Structural and Chemical Biology, and Medical Education. He is also Associate Dean in the Graduate School of Biomedical Sciences. Most recently, Dr. Hanss was appointed as Director of Educational Programs for the Mount Sinai Institute of Technology. He received a Bachelor’s Degree from Lewis and Clark College where he studied Biology, and a Ph.D. in Physiology from Tulane University. He spent a year at the National Institutes of Health as a Postdoctoral Fellow before joining the faculty at Mt. Sinai as a Research Assistant Professor in 1996. Dr. Hanss’s research focuses on discovering the mechanisms by which nucleic acids cross cell membranes. This poorly understood mechanism is important in nucleic acid signaling systems and in the successful deployment of naked DNA or RNA therapeutic technology. In addition, Dr. Hanss's lab focuses on development of technologies derived from his basic science research. Dr. Hanss is involved in classroom teaching and educational administration as well. He has taught medical and graduate students for more than 25 years at several institutions including Tulane University, the MIT/Harvard M.D./Ph.D. training program, and Mt. Sinai School of Medicine. Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU] Education BS, Lewis and Clark College PhD, Tulane University NIDR/NIH

Research Interest

Bioinformatics, Biophysics, Cell Biology, Epithelial Cells, Gene Therapy, Intracellular Transport, Kidney, Membrane Proteins/Channels, Membranes, Molecular Biology, Nanotechnology, Protein Complexes, Protein Structure/Function, Proteomics, Structural Biology, Transporters

Publications

  • Hanss B, Leal-Pinto E, Bruggeman LA, Copeland TD, Klotman PE (1998) Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci USA 95: 1921-1926.

  • Langer JC, Klotman ME, Hanss B, Tulchin N, Bruggeman LA, etal (1998) Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery. Exp Nephrol 6: 189-94.

  • Hanss B, Stein CA, Klotman PE (1998) Cellular Uptake and Biodistribution of Oligodeoxynucleotides. In: Stein CA, Krieg AM, editors. Applied antisense oligonucleotide technology. New York PP: 111-127.

  • Lipkowitz MS, Klotman ME, Bruggeman LA, Nicklin P, Hanss B, etal (1996) Molecular therapy for renal diseases. Am J Kidney Dis 28: 475-92.

  • Leal-Pinto E, Hanss B, Klotman PE (1996) Calcium regulation of a cell surface nucleic acid channel. Kidney Int Suppl 57: 4-10.

  • Rappaport J, Hanss B, Kopp JB, Copeland TD, Bruggeman LA, etal (1995) Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy. Kidney Int 47: 1462-1469.

  • Hanss BG, Lewy JE, Vari RC (1994) Alterations in glomerular dynamics in congenital, unilateral hydronephrosis. Kidney Int 46: 48-57.

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