Dara L Dickstein
DJUNCT ASSISTANT PROFESSOR
Neuroscience
Icahn School of Medicine at Mount Sinai
United States of America
Biography
Dr. Dickstein is currently an Assistant Professor in the Department of Neuroscience at Mount Sinai School of Medicine. Her educational background is in molecular genetics and immunology. Her PhD work was focused on the role of inflammation in Alzheimer’s disease (AD) pathogenesis and utilized transgenic animal models along with various biochemical and anatomical techniques. Dr. Dickstein continued in the field of AD in her postdoctoral fellowship, exploring the structural changes in neurons and synapses with disease progression. Currently, Dr. Dickstein's research is directed towards the study of selective neuronal vulnerability in ageing, dementia, and other neurodegenerative disorders using classical neuropathological as well as modern quantitative methods. Dr. Dickstein has established much national and international collaboration, and has become an expert in the techniques of intracellular injections, fluorescence quantification, confocal and electron microscopy. Dr. Dickstein is a co-PL in the Alzheimer’s Disease Research Center at Mount Sinai and a member of the Computational Neurobiology and Imaging Center (CNIC) at Mount Sinai. As a member of CNIC, she has contributed to the creation of an automated quantitative software tool (NeuronStudio) that enables accurate 3D analysis of individual neurons in the brain at very high resolution.
Research Interest
Aging, Alzheimer's Disease, Blood-Brain Barrier, Cancer, Synapses, Transgenic Mice
Publications
-
Dickstein DL, Biron K, Ujiie M, Jefferies WA (2006) Aß peptide immunization restored blood-brain barrier integrity in Alzheimer disease. FASEB Journal 20: 426-433.
-
Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, etal (2012) Amyloid precursor protein (APP) regulates synaptic structure and function. Molecular and cellular neurosciences Vol: 51.
-
Yadav A, Gao YZ, Rodriguez A, Dickstein DL, Wearne SL, etal (2012) Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. The Journal of comparative neurology.
-
Dickstein DL, Weaver CM, Luebke JI, Hof PR (2013) Dendritic spine changes associated with normal aging. Neuroscience Vol: 215
-
Dickstein DL, Weaver CM, Luebke JI, Hof PR (2013) Dendritic spine changes associated with normal aging. Neuroscience Vol:251.
-
Mitsis EM, Riggio S, Kostakoglu L, Dickstein DL, Machac J, etal (2014) Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury. Translational psychiatry Vol: 4.
