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Diabetes & Endocrinology Experts

Derek Leroith

Professor
Medicine, Endocrinology, Diabetes and Bone Disease
Icahn School of Medicine at Mount Sinai
United States of America

Biography

Internationally known for his research in Diabetes, Derek LeRoith, MD, PhD, is Professor of Medicine (Endocrinology, Diabetes and Bone Diseases) and Interim Chief of the Hilda & J. Lester Gabrilove Division of Endocrinology, Diabetes and Bones Diseases. Dr. LeRoith received his MD and PhD from the University of Capetown where he also completed his residency and both a research and clinical fellowship in Endocrinology. Prior to joining the faculty of the Icahn School of Medicine at Mount Sinai in 2005, Dr. LeRoith was Chief of the Diabetes Branch at the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. This is the largest program devoted to the study of diabetes within the intramural program of the NIH. He was recruited to Mount Sinai to become the Chief of the Endocrine Division at Mount Sinai as well as the Director of the Metabolism Institute. In 2010 he became the Director of Research for the Division of Endocrinology before returning to his duties as chief in 2015. Dr. LeRoith was the first to demonstrate the link between insulin and the insulin-like growth factor-1 (IGF-1) and cancer and is the current recipient of an three NCI grants to study the relationship between cancer and type 2 diabetes. He has published over 600 original research papers, reviews and editorials and edited a number of books on Diabetes and IGF-related topics. He is also the senior editor of a major textbook on Diabetes, now in its third edition, as well as Editor-in-Chief of Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists. Please visit the Leroith Laboratory.

Research Interest

Medicine, Endocrinology, Diabetes and Bone Disease

Publications

  • Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, etal (2009) Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.. FASEB J 23: 709-719.

  • Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, etal (2008) The role of insulin receptor signaling in zebrafish embryogenesis.. Endocrinology 149: 5996-6005.

  • Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, etal (2008) Insulin-like growth-factor-1 protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.. Cell Death Differ 15: 1304-1317.

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