Djamel Lebeche
ASSOCIATE PROFESSOR
Medicine, Cardiology
Icahn School of Medicine at Mount Sinai
United States of America
Biography
Dr. Lebeche is currently an Associate Professor of Medicine and a Graduate Faculty, Graduate School of Biological Sciences at the Icahn School of Medicine at Mount Sinai, New York (ISMMS). Dr. Lebeche graduated from the Department of Physiology at Boston University School of Medicine where he received his Master’s and PhD degrees in Molecular Physiology. After completing his post-doctoral training at Massachusetts General Hospital/Harvard Medical School, Boston, he was appointed as instructor in Medicine at Harvard Medical School before joining ISMMS and assuming his current position at the Cardiovascular Research Center. Dr. Lebeche is currently an independent principal investigator at ISMMS; his Laboratory’s research program currently focuses on identifying genes and molecular signaling pathways that influence cardiac physiology and related cardiometabolism dysregulation. We aim to provide new insights in the genetic and cellular mechanisms that regulate diabetic heart failure and the risk of metabolic disease with an eye toward genetic and pharmacological therapeutic interventions. Multi-Disciplinary Training Area Biophysics and Systems Pharmacology [BSP]
Research Interest
Apoptosis/Cell Death, Autophagy, Cardiovascular, Cellular Differentiation, Diabetes, Electrophysiology, Fibrosis, Gene Expressions, Gene Regulation, Gene Therapy, Human Genetics and Genetic Disorders, IGF-1 Receptor, Insulin, Insulin Receptor, Lipid Signaling, Liver, Membrane Proteins/Channels, Microarray, Mitochondria, Muscle Cells, Muscular Dystrophy, Obesity, Oxidative Phosphorylation, Oxidative Stress, Proteomics, Receptors, Signal Transduction, Stem Cells, Transcription Factors, Transgenic Mice
Publications
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Lebeche D (2015) Diabetic cardiomyopathy: is resistin a culprit?. Cardiovasc Diagn Ther. 5: 387-393.
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Tong X, Kono T, Anderson-Baucum E, Yamamoto W, Gilon P, Lebeche D, etal (2016) SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. . Diabetes 65: 3039-3052.
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Kang S, Dahl R, Hsieh W, Shin A, Zsebo K, etal (2016) Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders.J Biol Chem 291: 5185-1598.