Doris Germain
Professor
Medicine, Hematology and Medical Oncology and Oncological Sc
Icahn School of Medicine at Mount Sinai
United States of America
Biography
Doris Germain at present is professor in the field of Medicine, Hematology and medical oncology at ICHAN school of medicineat Mount siani.Her Multi-Disciplinary Training Area include Cancer Biology [CAB]. Her Education BSc from McGill University and PhD from Montreal University.
Research Interest
Cancer, Cell Cycle, Hormones, Mitochondria, Oncogenes, Protein Degradation, Protein Folding, Receptors
Publications
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Chandler H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D (2011) Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4 [abstract]. PLOS One. 6: 22456.
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Ishii Y, Papa L, Bahadur U, Yue Z, Aguirre-ghiso J, Shioda T, Waxman S, Germain D (2011) Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a pro-apoptotic unfolded protein response [abstract]. Clinical Cancer research. 17: 2292.
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Chandler H, Halpern M, Resnick-Silverman L, Manfredi JJ, Germain D (2010) Skp2B attenuates p53 function by inhibiting prohibitin [abstract]. EMBO reports. 11: 220.
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Ishii Y, Waxman S, Germain D (2008) Tamoxifen stimulates the growth of cyclin D1 overexpressing breast cancer cells by promoting the activation of STAT3 [abstract]. Cancer Research. 68: 852.
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Papa L, Germain D (2011) The estrogen receptor mediates a novel mitochondrial unfolded protein response [abstract]. Journal of Cell Science. 124: 1396.
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Radke S, Chandler H, Schäfer P, Meiss G, Krüger R, etal (2014) SOD2 to SOD1 switch in breast cancer [abstract]. Journal of Biological Chemistry. 289: 5412-5416.
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Papa L, Germain D (2014) SirT3 regulates the mitochondrial unfolded protein response [abstract]. Molecular and Cellular Biology. 34: 699-710.
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Takabatake Y, Oxvig C, Nagi C, Adelson K, Keely PJ, etal (2016) Post-partum involution unleashes the oncogenic function of Pappalysin-1 to promote pregnancy-associated breast cancer [abstract]. EMBO Molecular Medicine. 8:. 388-406.
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Adelson (2016) Randomized Phase II Trial of Fulvestrant Alone or in Combination with Bortezomib in Hormone Receptor-Positive Metastatic Breast Cancer Resistant to Aromatase Inhibitors: A New York Cancer Consortium Trial [abstract]. Nature Breast Cancer.
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Germain D (2016) Selected mitochondrial DNA landscapes activate SOD2 and the UPRmt to promote metastasis. Submitted.
