George W Huntley
Professor
Neuroscience
Icahn School of Medicine at Mount Sinai
United States of America
Biography
Dr. Huntley's laboratory uses multidisciplinary approaches to investigate mechanisms through which strength and organization of synaptic connection are modified during development, by experience, and following brain, spinal cord or peripheral nerve injury.
Research Interest
Anatomy, Autism, Axon Guidance, Brain, Cell Adhesion, Cerebral Cortex, Developmental Neurobiology, Electrophysiology, Extracellular Matrix, Memory, Neurophysiology, Neuroscience, Neurotransmitters, Regeneration, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Publications
-
Bozdagi O, Nagy V, Kwei KT, Huntley GW (2007) In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. J Neurophysiology 98: 334-344.
-
Nagy V, Bozdagi O, Huntley GW (2007) The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory. Learning and Memory 14: 655-664.
-
Kichula EA, Huntley GW (2007) Developmental and comparative aspects of posterior medial thalamocortical innervation of barrel cortex in mice and rats. J Comp Neurol 509: 239-258.
-
Wang XB, Bozdagi O, Nikitczuk JS, Zhai ZW, Zhou Q, etal (2008) Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately. Proc Natl Acad Sci USA 105: 19519-19524.
-
Bozdagi O, Wang X, Nikitczuk JS, Anderson TR, Bloss EG, etal (2010) Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci 39: 9984-9989.
-
Aujla PK, Huntley GW (2014) Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry. J Comp Neurol 522: 1249-1263.
-
Nikitczuk JS, Patil SB, Matikainen-Ankney BA, Scarpa J, etal (2014) N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus 24: 943-962.
-
Carcea I, Patil SB, Robison AJ, Mesias R, Huntsman MM, etal (2014) Maturation of cortical circuits requires Semaphorin 7A. Proceedings of the National Academy of Sciences of the United States of America 111: 13978-13983.
-
Friedman LG, Riemslagh FW, Sullivan JM, Mesias R, Williams FM, etal (2015) Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. The Journal of comparative neurology.
-
Friedman L, Benson D, Huntley GW (2015) Cadherin-based trans-synaptic networks in establishing and modifying neural connectivity. Current Topics Dev Biol 112: 415-465.
