Genetics and Genomic Sciences,Neuroscience and Psychiatry
Icahn School of Medicine at Mount Sinai
United States of America
Kristen Brennand is a stem cell biologist working to bridge the fields of developmental neuroscience and psychiatry. A major focus of her work is developing in vitro models for schizophrenia in order to identify novel insights into the molecular and cellular phenotypes of mental illness. Multi-Disciplinary Training Areas Clinical Research Education Program [CLR], Developmental and Stem Cell Biology [DSCB], Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
Gene Expressions, Human Genetics and Genetic Disorders, Migration, Schizophrenia, Stem Cells, Synaptogenesis
Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, etal (2011) Modelling schizophrenia using human induced pluripotent stem cells. Nature 473: 221-225.
Yu DX, Di Giorgio FP, Yao J, Marchetto MC, Brennand K, etal (2014) Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem cell reports Vol: 2.
Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, etal (2014) Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron Vol: 82.
McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, etal (2013) Mosaic copy number variation in human neurons. Science Vol: 342.
Brennand K, Savas JN, Kim Y, Tran N, Simone A, etal (2014) Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular psychiatry.
Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, etal (2014) Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem cell reports Vol: 3.
Topol A, Zhu S, Tran N, Simone A, Fang G, Brennand KJ (2015) Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients. Biological psychiatry Vol 78.
Hartley BJ, Tran N, Ladran I, Reggio K, Brennand KJ (2014) Dopaminergic differentiation of schizophrenia hiPSCs. Molecular psychiatry Vol: 20.
Topol A, Tran NN, Brennand KJ (2015) A guide to generating and using hiPSC derived NPCs for the study of neurological diseases. Journal of visualized experiments : JoVE Vol: 96.
Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, etal (2015) Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature.