Lakshmi A Devi
Professor
Pharmacological Sciences,Neuroscience,Psychiatry
Icahn School of Medicine at Mount Sinai
United States of America
Biography
Dr. Devi is Professor of the Pharmacology and Systems Therapeutics, Psychiatry and Neuroscience departments. She is the Dean for Academic Development and Enrichment as well as Director of the Interdisciplinary Training in Drug Abuse Research Program. Throughout her career, she has been interested in several lines of research, including receptor dimerization, regulation of peptide biosynthesis and opiate addiction. Part of her research focus is to explore mechanisms underlying opiate and cannabinoid receptor activation using a combination of molecular biological, biochemical, cell biological, pharmacological and behavioral techniques. Some of the projects in her lab also use a combination of classic and modern techniques in molecular pharmacology to explore the novel pharmacology of receptor heterodimers, and/or cutting-edge neuroproteomic techniques to analyze morphine induced changes in the levels of synaptic proteins and neuropeptides.
Research Interest
Addiction, Enzymology, Hormones, Neural Networks, Neuropeptides, Opioid/Cannabinoid Receptors, Post-Transcriptional Processing, Protein Trafficking & Sorting, Proteomics, Signal Transduction
Publications
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Miller LK, Hou X, Rodriguiz RM, Gagnidze K, Sweedler JV, etal (2011) Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. Journal of Neurochemistry Vol: 119.
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Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, etal (2012) Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. PLoS One Vol 7.
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Filizola M, Devi LA (2012) Structural biology: How opioid drugs bind to receptors. Nature 485: 7398.
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Bushlin I, Gupta A, Stockton SD, Miller LK, Devi LA (2012) Dimerization with cannabinoid receptors allosterically modulates delta opioid receptor activity during neuropathic pain. PLoS One Vol: 7.
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Gomes I, Fujita W, Gupta A, Saldanha AS, Negri A, etal (2013) Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci USA Vol: 110.
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Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, etal (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci USA Vol: 110.
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Stockton SD, Devi LA (2014) An integrated quantitative proteomics and systems biology approach to explore synaptic protein profile changes during morphine exposure. Neuropsychopharmacology Vol: 39.
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Gupta A, Gomes I, Wardman J, Devi LA (2014) Opioid Receptor Function is Regulated by Post-endocytic Peptide Processing. Journal of Biological Chemistry.
