Paul J Kenny
Paul J Kenny
Neuroscience
Icahn School of Medicine at Mount Sinai
United States of America
Biography
aul J. Kenny, PhD, is Ward-Coleman Professor and Chair of the Arthur M. Fishberg Department of Neuroscience. Dr. Kenny also serves as the Director of the Drug Discovery Institute. His multidisciplinary research involves the study of behavioral paradigms, physiological analyses, and the molecular underpinnings of neurobehavioral disorders. Dr. Kenny is actively investigating the brains of rodents to uncover new signaling cascades that may play a role in addiction-like behaviors. The Kenny Laboratory is focused on understanding the neurobiological mechanisms of drug addiction, obesity and schizophrenia, with an emphasis on the role of nicotinic acetylcholine receptors (nAChRs) in these processes. They employ a multidisciplinary approach that includes complex behavioral paradigms, physiological analyses and molecular biological techniques. Current projects include the utilization of vector-based delivery systems to modify gene expression in the brains of rodents to identify novel signaling cascades that may play a role in addiction-like behaviors. Search PubMed for articles Multi-Disciplinary Training Areas Biophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
Research Interest
Addiction, Behavior, Brain, Drug Design and Discovery, Epigenetics, Gene Expressions, Molecular Biology, Neurobiology, Neuroscience, Obesity, Schizophrenia
Publications
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Bali P, Im HI, Kenny PJ (2011) Methylation, memory and addiction. Epigenetics vol: 6.
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Heyer MP, Pani AK, Smeyne RJ, Kenny PJ, Feng G (2012) Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice. Journal of Neuroscience Vol: 32.
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Hope BT, Skinner MK, Kenny PJ, Akbarian S (2013) Exploring the epigenetics of cocaine resistance. Nature Medicine Vol: 19.
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Jiang R, Song X, Bali P, Smith A, Bayona CR, Lin L, etal (2012) Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists. Bioorganic and Medicinal Chemistry Letters Vol: 22.
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Kenny PJ (69) Reward mechanisms in obesity: new insights and future directions. Neuron Vol: 4.
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Im HI, Hollander JA, Bali P, Kenny PJ (2010) MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nature Neuroscience Vol; 13.
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Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, etal (2010) Striatal microRNA controls cocaine intake through CREB signalling. Nature Vol: 466.
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Damez-Werno DM, Kenny PJ (2015) Using opioid receptors to expand the chemogenetic and optogenetic toolbox. Neuron Vol: 86.
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Wang J, Kuryatov A, Sriram A, Jin Z, Kamenecka TM, etal (2015) An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors. The Journal of biological chemistry Vol: 290.
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Chen Z, Kenny PJ (2015) Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity. Cell metabolism Vol: 22.
