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Saurabh Mehandru

ASSISTANT PROFESSOR
Medicine, Gastroenterology
Icahn School of Medicine at Mount Sinai
United States of America

Saurabh Mehandru

Biography

Dr. Mehandru straddles the world of clinical care and laboratory based investigation. He graduated from the University College of Medical Sciences, Delhi University, India and then completed residency training in Internal Medicine at the NYU School of Medicine where he also served as Medical Chief Resident. He received subspecialty training in Clinical Gastroenterology at The Icahn School of Medicine at Mount Sinai. Dr. Mehandru undertook post-doctoral training at the Rockefeller University, first working in the Laboratory of Dr. David Ho (with Dr. Martin Markowitz) and then in the Laboratory of Dr. Ralph Steinman, Nobel Laureate in Physiology or Medicine (2011). During this period, Dr. Mehandru, reported on the preferential depletion of gut lymphocytes during acute HIV-1 infection and on the lack of immune reconstitution in the GI tract following years of apparently suppressive antiretroviral therapy. After finishing his post-doctoral training, Dr. Mehandru was invited to join the faculty at Mount Sinai where in addition to serving as an Assistant Professor of Gastroenterology, he leads a laboratory of Mucosal Immunology since 2013. Dr. Mehandru’s research interests include mucosal trafficking, the host-pathogen interface, dendritic cell biology and mucosal immunopathology in primary and acquired immunodeficiency states. He is an NIH-funded investigator who has received multiple awards.

Research Interest

AIDS/HIV, Aging, Antigen Presentation, Autoimmunity, B Cells, Cell Adhesion, Cell Biology, Cellular Immunity, Chemokines, Cytokines, Dendritic Cells, Epithelial Cells, Gene Expressions, Hepatitis C Virus, Immune Deficiency, Immunology, Immunosuppression, Infectious Disease, Inflammation, Integrins, Knockout Mice, Lung, Lymphocytes, Macrophage, Microarray, Mucosal Immunology, Retinoic Acid, Retrovirus, T Cells, Trafficking

Publications

  • Lee H, Ruane D, Law K, Ho Y, Garg A, etal (2015) Phenotype and function of nasal dendritic cells. Mucosal immunology.

  • Ruane D, Do Y, Brane L, Garg A, Bozzacco L, etal (2016) A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract. Mucosal immunology.

  • Ruane D, Chorny A, Lee H, Faith J, Pandey G, Shan M, etal (2016) Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses. The Journal of experimental medicine Vol: 213.

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