Tuan M. Tran, Md, Phd
Assistant Professor of Medicine
Pediatrics
Indiana University
United States of America
Biography
EDUCATION 1999 B.S. (Zoology), University of Florida 2005 Ph.D. (Immunology), Emory University 2007 M.D., Emory University School of Medicine 2008-2010 Residency (Internal Medicine), The Johns Hopkins Hospital 2011-2015 Fellowship (Infectious Diseases), National Institute of Allergy and Infectious Diseases, National Institutes of Health
Research Interest
SPECIALTY Systems biology of human malaria Malaria immunity and infection biology AREAS OF INTEREST The focus of our lab is to define mechanisms of host immunity to malaria and identify immune correlates of protection from Plasmodium falciparum infection by studying naturally acquired immunity in individuals living in malaria-endemic communities using systems biology approaches. Dr. Tran's primary research interests are in defining mechanisms of host immunity to malaria in malaria-endemic settings. By investigating naturally acquired immunity to malaria, Dr. Tran believes we can gain a better understanding as to why malaria vaccines that perform well in naïve donors have performed less effectively in the field. As such, the majority of his research has focused on immune responses to Plasmodium parasites in individuals who are naturally exposed to malaria.
Publications
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Arama C, Skinner J, Doumtabe D, Portugal S, Tran TM, et al. Genetic Resistance to Malaria Is Associated With Greater Enhancement of Immunoglobulin (Ig)M Than IgG Responses to a Broad Array of Plasmodium falciparum Antigens. Open forum infectious diseases. 2015; 2(3):ofv118. PubMed PMID: 26361633, PMCID:PMC4564391
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Obeng-Adjei N, Portugal S, Tran TM, Yazew TB, Skinner J, et al. Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children. Cell reports. 2015; 13(2):425-39. NIHMSID: NIHMS721051 PubMed PMID: 26440897, PMCID: PMC4607674
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Gordon EB*, Hart GT*, Tran TM*, Waisberg M, Akkaya M, et al. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(42):13075-80. PubMed PMID: 26438846, PMCID: PMC4620853; *Authors contributed equally to this work.
