Biochemistry
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Biochemistry Experts

Anthony K. L. Leung

Associate Professor
Biochemistry and Molecular Biology
Johns Hopkins Bloomberg School of Public Health
United States of America

Anthony K. L. Leung

Biography

Dr. Anthony Leung – a scientist and an inventor – is an expert in the area of RNA, ADP-ribosylation and proteomics. Dr. Leung completed his four-year Master in Biochemistry degree at the Exeter College, University of Oxford. Funded by the Croucher Scholarship from Hong Kong and Overseas Research Scheme from United Kingdom, Dr. Leung earned his Ph.D. in Biochemistry from the University of Dundee under the guidance of Dr. Angus I. Lamond. Using quantitative proteomes and imaging approaches, Dr. Leung characterized the nucleolar proteome dynamics and discovered a novel nucleolar localization pathway during his Ph.D. In 2004, Dr. Leung was awarded the Human Frontier Science Program Long-term Fellowship and, subsequently in 2007, a Special Fellowship from The Leukemia & Lymphoma Society to perform postdoctoral research on microRNAs under the mentorship of Nobel Laureate Dr. Phillip A. Sharp at MIT. In 2010, Dr. Leung hold a secondary postdoctoral appointment with Dr. Paul Chang at MIT on investigating a therapeutically important protein modification called ADP-ribosylation. Dysregulation of ADP-ribosylation metabolism results in neurodegenerative disorders, virus infection and cancer susceptibility.

Research Interest

Poly(ADP-ribose), microRNAs, Cancers, RNA regulation, RNA granules

Publications

  • Leung AK. Poly(ADP-ribose): An organizer of cellular architecture. Journal of Cell Biology 2014 PMID: 24914234

  • Daniels CM, Ong SE, Leung AK. The Promise of Proteomics for the Study of ADP-ribosylation. Molecular Cell 2015 PMID: 26091340

  • McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. Proceedings of the National Academy of Sciences of the United States of America. 2017 PMID: 28143925

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