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Pathology Experts

Charles George Eberhart

Professor of Pathology
Pathology
Johns Hopkins University
United States of America

Biography

Dr. Charles Eberhart is a professor of pathology and oncology, and an associate professor of ophthalmology, at the Johns Hopkins University School of Medicine. His research primarily focuses on molecular genetics and treatment of medulloblastoma, glioblastoma, uveal melanoma and other tumors of the brain and eye. Dr. Eberhart serves as the director of the Divisions of Neuropathology and Ophthalmic Pathology. Major research areas in his laboratory include targeting Notch and other developmentally important signaling pathways in tumors, identifying the genetic drivers of rare neoplasms in the brain and eye, and building new models of tumors using neural stem cells. He received his undergraduate degree in biochemistry from the University of Texas at Austin and earned his M.D./Ph.D. from UT Southwestern Medical School. He also was a fellow at the Max Planck institute for one year. Dr. Eberhart completed both a residency in anatomic pathology and a fellowship in neuropathology at The Johns Hopkins Hospital, then joined the Johns Hopkins faculty in 2001. Dr. Eberhart has been recognized with the Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians, and career development awards from the Burroughs Wellcome Fund and the National Institutes of Health. He has published more than 200 original research articles, numerous case reports, reviews and book chapters, and is on the editorial board of the Journal of Neuro-Oncology, Brain Pathology and the Journal of Neuropathology and Experimental Neurology.

Research Interest

Pathology

Publications

  • Chu Q, Orr BA, Semenkow S, Bar EE, Eberhart CG. Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following In Vivo Notch Blockade. Clin Cancer Res 2013;19(12):3224-33.

  • Pierfelice TJ, Schreck KC, Dang L, Asnaghi L, Gaiano N, Eberhart CG. Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner. Cancer Res 2011; 71;1115-25.101.

  • Raabe EH, Lim KS, Kim JM, Meeker A, Mao XG, Nikkhah G, Maciaczyk J, Kahlert U, Jain D, Bar E, Cohen KJ, Eberhart CG. BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model. Clin Cancer Res. 2011;17(11):3590-9.

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