Liam Lucian Chen
Assistant Professor
Pathology
Johns Hopkins University
United States of America
Biography
Dr. Liam Chen is an assistant professor of pathology at the Johns Hopkins University School of Medicine. His research focuses on understanding the pathogenesis of neurodegenerative disorders and CNS tumors. His primary clinical involvement is on the neuropathology service. Dr. Chen earned his M.D. from Shandong Medical University in China and his Ph.D. from the University of Alberta in Canada. He was subsequently a postdoctoral fellow at Harvard Medical School, and completed Anatomic Pathology/Neuropathology training at Brigham and Women’s Hospital, Boston Children's Hospital and a Molecular Genetic Pathology fellowship at Harvard Medical School.
Research Interest
Pathogenesis of neurodegenerative disorders
Publications
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Nosho K, Shima K, Irahara N, Kure S, Firestein R, Baba Y, Toyoda S, Chen L, Hazra A, Giovannucci EL, Fuchs CS, Ogino S. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol. 2009. 22(7):922-32.
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Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB. "Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation." J Clin Invest. 2009. 119(11):3257-65
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Chen L, Feany MB. "Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease." Nat Neurosci. 2005. 8(5):657-63
