Paul R. Hanson
Chancellors Club Teaching Professor
Department of Chemistry
Kansas City University of Medicine and Biosciences
United States of America
Biography
The Hanson group has an ongoing interest in the development of novel methods for the design and synthesis of diverse S- and P-heterocycles as potential small molecule drug probes/leads. Utilizing a diversity-oriented synthesis (DOS) approach in combination with a variety metrics (bioinformatics), a number of protocols have been recently developed to access collections of diverse S-heterocycles, namely sultams.
Research Interest
Synthetic methods, natural product synthesis, transition metal-catalyzed methods, asymmetric methods, S- and P-heterocycles, immobilized reagent development, drug discovery and delivery, and chemical methods for library development.
Publications
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Rolfe, A.; Young, K.; Volp, K.; Schoenen, F.; Neuenswander, B.; Lushington, G. H.; Hanson, P. R. A One-Pot, 3-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1,2-benzisothiazoline-3-acetic acids. J. Comb. Chem. 2009, 11, 732-738 Jeon, K.; Rayabarapu, D.; Rolfe, A.; Volp, K.; Omar, I.; Hanson, P. R. Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams Tetrahedron 2009, 65, 4992-5000 Dinesh Kumar Rayabarapu, Aihua Zhou, Kyu Ok Jeon, Thiwanka Samarakoon, Alan Rolfe, Hina Siddiqui, Paul R. Hanson α-Haloarylsulfonamides: multiple cyclization pathways to skeletally diverse benzofused sultams Tetrahedron 2009, 65, 3180-3188
