Alexander H. Hoon
Kennedy Krieger Institute
United States of America
BIOGRAPHICAL SKETCH: Dr. Hoon received a bachelor's of science from Davidson College in 1974, and a medical degree from the University of Pittsburgh in 1978. After a pediatric residency at Kosair-Children's Hospital in Louisville and two years in private practice, he completed a neonatology fellowship at British Columbia Children's Hospital and a one-year fellowship in medical genetics at the Affiliated Hospitals in Vancouver, Canada. In 1988, he came to Baltimore where he completed a fellowship in neurodevelopmental disabilities at Kennedy Krieger Institute, and obtained a master's of public health at Johns Hopkins School of Hygiene and Public Health. He joined the Kennedy Krieger faculty in 1990. Dr. Hoon is the director of the Phelps Center for Cerebral Palsy and Neurodevelopmental Medicine at the Kennedy Krieger Institute. He is also the medical director of the Carter Center for Holoprosencephaly and Related Disorders at Johns Hopkins and Kennedy Krieger Institute, and is an attending physician at Kennedy Krieger Children's Hospital and Johns Hopkins Children's Center. RESEARCH SUMMARY: Cerebral palsy, the most common form of chronic motor disability beginning in childhood, is often related to events before birth affecting brain development. Modern imaging techniques, including conventional brain MRI and diffusion tensor imaging (DTI), can now be utilized to establish cause and refine treatment for children, adolescents and adults with cerebral palsy. The ongoing development of these imaging techniques to more precisely characterize brain injury and quantitative measurement tools to evaluate the success of rehabilitative interventions is essential to improve care for affected individuals. Dr. Hoon, utilizing training in neonatology, genetics, neurodevelopmental disabilities and public health and working with collaborative research teams, addresses questions of cause and treatment in cerebral palsy. Past publications have addressed causal factors, quantification of the severity of functional impairment, and treatment with oral medications. Current research utilizes advanced neuroimaging techniques in the Kennedy Krieger Institute Kirby Research Center for Functional Brain Imaging, including DTI to more precisely characterize brain injury. These imaging modalities will allow researchers studying rehabilitative interventions to assign children with cerebral palsy to cohorts with comparable levels of injury.
"1. Yahyavi-Firouz-Abadi N, Poretti A, Idowu OR, Hoon AH Jr, Huisman TA, Izbudak I. Case 236. Radiology (2016) 280: 640-642. 2. Jiam NT, Hoon AH Jr, Hostetter CF, Khare MM. IIAM (important information about me): a patient portability profile app for adults, children and families with neurodevelopmental disabilities. Disabil Rehabil Assist Technol (2016) pp.1-6. 3. Hoon AH Jr, Stashinko EE. Neuroimaging: connecting the pixels. Dev Med Child Neurol (2011) 53: 482. 4. Hoon AH Jr, Vasconcellos Faria A. Pathogenesis, neuroimaging and management in children with cerebral palsy born preterm. Dev Disabil Res Rev (2010) 16: 302-312. 5. Hoon AH Jr, Stashinko EE, Nagae LM, Lin DD, Keller J, Bastian A, Campbell ML, Levey E, Mori S, Johnston MV. Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways. Dev Med Child Neurol (2009) 51: 697-704.