Lisa Kratz
DirectorÂ
 Biochemical GeneticsÂ
Kennedy Krieger Institute
United States of America
Biography
BIOGRAPHICAL SKETCH: Dr. Kratz received her Bachelor of Arts degree from Western Maryland College in 1985, and her doctorate in human genetics from the University of Maryland at Baltimore in 1989. She completed a post-doctoral fellowship in biochemical genetics at the University of Colorado Health Sciences Center in 1991, and was the assistant director of the Biochemical Diseases Detection Laboratory at Yale University from 1991 to 1993. Dr. Kratz was certified by the American Board of Medical Genetics and Genomics in biochemical genetics in 1993 and is a member of the Society For Inherited Metabolic Disorders (SIMD) and the Society for the Study of Inborn Errors of Metabolism (SSIEM). She has been with the Kennedy Krieger Institute since 1993. RESEARCH SUMMARY: Dr. Kratz’s interests focus on the diagnosis of certain inborn errors of metabolism and clinical research related to these disorders. One area of interest involves disorders of cholesterol biosynthesis including Smith-Lemli-Opitz syndrome, Desmosterolosis, X-Linked Dominant Conradi Hünermann Syndrome, and SC4MOL deficiency. Other areas of interest include disorders of creatine synthesis and transport, Barth syndrome, and Mevalonate Kinase deficiency.
Research Interest
Biochemical Genetics
Publications
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"1. Wassif CA, Kratz L, Sparks SE, Wheeler C, Bianconi S, Gropman A, Calis KA, Kelley RI, Tierney E, Porter FD. A placebo-controlled trial of simvastatin therapy in Smith-Lemli-Opitz syndrome. Genet Med (2016). 2. Kratz LE, Albert JS. 2-Ethylhexanoic acid, found in common plasticizers, leads to an artificial increase in C8 acylcarnitine levels in two neonates treated with extracorporeal membrane oxygenation (ECMO). Clin Chim Acta (2016). 461: 59-60. 3. Driver AM, Kratz LE, Kelley RI, Stottmann RW. Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain. Neurobiol Dis (2016) 91: 69-82. 4. Gabitova L, Restifo D, Gorin A, Manocha K, Handorf E, Yang DH, Cai KQ, Klein-Szanto AJ, Cunningham D, Kratz LE, Herman GE, Golemis EA, Astsaturov I . Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep (2015) 12: 1927-1938. 5. Herman GE, Kratz L (2012). Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome. Am J Med Genet C Semi (2012).
