Lakshmi Balagopalan
Scientist
Cellular and Molecular Biology
Laboratory of Cell and Molecular Biology
United States of America
Biography
Dr. Lakshmi Balagopalan began her scientific career as a student researcher in the Genetics Research Program at the University of Calcutta, India. She learned how to handle flies as a student volunteer at the Center for Cellular and Molecular Biology (CCMB), Hyderabad, India, before she joined the genetics graduate program at Pennsylvania State University in 1997. She earned her Ph.D. studying the role of genes involved in myogenesis and myoblast fusion in Drosophila melanogaster. In 2003 she joined the Laboratory of Cellular and Molecular Biology at NCI as a Cancer Research Training Award (CRTA) postdoctoral fellow. She was promoted to research fellow in 2006 and staff scientist in 2011. Dr. Balagopalan is an active member of the Staff Scientist and Staff Clinician (SSSC) community at CCR, serving as section editor of the SSSC newsletter (The Dossier). She is the recipient of several awards, including the Federal Technology Transfer Award and the NCI Director's Innovation Award.
Research Interest
Signal transduction, T cells, LAT, Trafficking, Ubiquitin
Publications
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Balagopalan L, Barr VA, Samelson LE. Endocytic events in TCR signaling: focus on adapters in microclusters. Immunological reviews. 2009 Nov 1;232(1):84-98.
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Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE. Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation. Proceedings of the National Academy of Sciences. 2011 Feb 15;108(7):2885-90.
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Balagopalan L, Sherman E, Barr VA, Samelson LE. Imaging techniques for assaying lymphocyte activation in action. Nature Reviews Immunology. 2011 Jan 1;11(1):21-33.
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Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE. Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. The Journal of Immunology. 2013 Apr 15;190(8):3849-53.
