Lawrence E. Samelson
Senior Investigator
Cellular and Molecular Biology
Laboratory of Cell and Molecular Biology
United States of America
Biography
Dr. Samelson received his M.D. degree from Yale University in 1977. Following training in internal medicine at the University of Chicago, he carried out postdoctoral research at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases. He joined the Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development in 1985, became senior investigator in 1988, and chief of the Section on Lymphocyte Signaling and deputy branch chief in 1995. He became chief of the Laboratory of Cellular and Molecular Biology, NCI, in 1999.
Research Interest
Lymphocyte activation, Signal transduction, T cell antigen receptor structure, physiology and ontogeny, Protein kinases, Adapter molecules
Publications
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Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
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Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. The Journal of cell biology. 2002 Sep 30;158(7):1263-75.
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Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE. Absence of both Sosâ€1 and Sosâ€2 in peripheral CD4+ T cells leads to PI3K pathway activation and defects in migration. European journal of immunology. 2015 Aug 1;45(8):2389-95.
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Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE. The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters. Journal of Biological Chemistry. 2015 Oct 30;290(44):26422-9.
