Michael Bustin
Senior Investigator
Metabolism
Laboratory of Metabolism National Cancer Institute Center for Cancer Research
United States of America
Biography
Michael Bustin received his Ph.D. from University at California, Berkeley and did postdoctoral work in the area of protein chemistry, in the laboratory of Drs. S. Moore and W. Stein at the Rockefeller University in New York, and in the area of immunochemistry at the Weizmann Institute of Science, Israel, where he produced antibodies to histones and pioneered their use for studies on chromatin structure and function. His research interests center on the role of chromosomal proteins in chromatin function, gene expression, development and cancer.
Research Interest
Chromatin structure and function, Chromatin binding proteins, High mobility group (HMG) nucleosome-binding proteins, Histone H1 function
Publications
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Deng T, Zhu ZI, Zhang S, Leng F, Cherukuri S, Hansen L, Mariño-RamÃrez L, Meshorer E, Landsman D, Bustin M. HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells. Molecular and cellular biology. 2013 Aug 15;33(16):3377-89.
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Rochman M, Postnikov Y, Correll S, Malicet C, Wincovitch S, Karpova TS, McNally JG, Wu X, Bubunenko NA, Grigoryev S, Bustin M. The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription. Molecular cell. 2009 Sep 11;35(5):642-56.
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Catez F, Ueda T, Bustin M. Determinants of histone H1 mobility and chromatin binding in living cells. Nature structural & molecular biology. 2006 Apr;13(4):305.
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Pash J, Popescu N, Matocha M, Rapoport S, Bustin M. Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. Proceedings of the National Academy of Sciences. 1990 May 1;87(10):3836-40.
