Gregory R. Nelson
Professor
Division of Biomedical Engineering Sciences
Loma Linda University
United States of America
Biography
Dr. Gregory R. Nelson is currently working as a Professor in the Department of Division of Biomedical Engineering Sciences, Loma Linda University , U.S.A. His research interests includes effects of ionizing radiation on normal cells and tissues. He /she is serving as an editorial member and reviewer of several international reputed journals. Dr. Gregory R. Nelson is the member of many international affiliations. He/ She has successfully completed his Administrative responsibilities. He /she has authored of many research articles/books related to effects of ionizing radiation on normal cells and tissues.
Research Interest
My current research interests center on the effects of ionizing radiation on normal cells and tissues. It is normal tissues which set limits on radiation doses used in cancer therapy and it is normal tissues which set risk limits for occupational radiation exposures. My laboratory investigates functional consequences of radiation exposure with emphasis on charged particle radiations such as protons, used at LLU for cancer therapy and accelerated ions of other elements (obtained at the Brookhaven National laboratory) that simulate cosmic rays encountered by astronauts. We look at the brain, the immune system and bone as tissues that are at risk from radiation exposure and measure functions such as electrical signal formation/propagation or the ability to generate immune memory. My interests in astronaut health also extend to effects of weightlessness and have involved experiments flown on five space shuttle missions. I am also interested in how cells communicate information with each other and use radiation from microbeams to target individual cells in the model organism C. elegans. These intestinal cells are able to generate signals that are received by unirradiated cells that in turn develop genotoxic damage. Genetic screening techniques provide a means of identifying components of the signaling pathway and controlling the irradiation permits analysis of cell cooperation in transmitting/receiving the “bystander” signals
Publications
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Vlkolinsky R, Titova E, Krucker T, Chi BB, Staufenbiel M, NELSON GA, Obenaus A. (2010) Exposure to 56Fe-particle radiation accelerates electrophysiological alterations in the hippocampus of APP23 transgenic mice. Radiat Res. 173(3):342-52. doi: 10.1667/RR1825.1. PubMed PMID: 20199219.
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Titova E, Adami A, Ostrowski R, Lalas S, Vlkolinsky R, Zhang JH, Nelson G, Obenaus A. (2010) Radiation exposure prior to ischemia decreases lesion volume, brain edema and cell death. Acta Neurochir Suppl. 106:51-3. PMID: 19812920.
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Sanchez MC, NELSON GA, Green LM. (2010) Effects of protons and HZE particles on glutamate transport in astrocytes, neurons and mixed cultures. Radiat Res. 174(6):669-78. doi: 10.1667/RR2106.1. Epub 2010 Sep 28. PubMed PMID: 21128790.