Sean Wilson

Biography

Dr. Sean Wilson is currently working as a Associate Professor in the Department of Division of Pharmacology, Loma Linda University , U.S.A. His research interests includes pulmonary vasculature. He is serving as an editorial member and reviewer of several international reputed journals. Dr. Sean Wilson is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to pulmonary vasculature.

Research Interest

The pulmonary vasculature is unique in that it regulates oxygenation of the blood. Before birth the fetal lung is only preparing for this role outside the womb. Although the mother protects the unborn child from the environment, the fetal lung adapts to maternal stresses. Ideally these adaptations would better prepare the newborn to meet the challenges of the outside world. Instead, they often result in pulmonary vascular disease. Regrettably, pulmonary hypertension of the newborn is an intractable disease with few effective treatments. Although a number of proteins have been identified that participate in the development of pulmonary vascular disease, the cell signaling pathways that regulate this process remain unclear. What is certain is that neuro-humoral substances bind to cell surface receptors and this activates intracellular signaling cascades. This includes Ca2+ that is fundamental to the development of pulmonary vascular disease. Our research aims to delineate the cellular processes central to Ca2+ signaling during lung development. Understanding these systems can provide new insights into pulmonary vascular disease and opportunities to develop novel therapies.