Xiao Wen “vivien” Mao

Biography

Dr. Xiao Wen “Vivien” Mao is currently working as a Associate Research Professor in the Department of Division of Biomedical Engineering Sciences, Loma Linda University , U.S.A. His research interests includes Radiation therapy is used alone or in combination with surgery and chemotherapy. she is serving as an editorial member and reviewer of several international reputed journals. Dr. Xiao Wen “Vivien” Mao is the member of many international affiliations. She has successfully completed his Administrative responsibilities. He /she has authored of many research articles/books related to Radiation therapy is used alone or in combination with surgery and chemotherapy .

Research Interest

Radiation therapy is used alone or in combination with surgery and chemotherapy in the care and management of nearly all adult and approximately 75% of pediatric patients with central nervous system (CNS) malignancies. High-grade brain tumors are among the most radio-resistant of all cancers. The total radiation dose needed for cure exceeds the tolerance of normal blood vessels. Both the dose response of the vasculature of a cancer being treated and the response of the vasculature in surrounding normal tissues are important parameters. My research focus on investigating response of normal tissues to irradiation, particularly, radiation-induced changes in normal vasculature in the CNS. Currently, there are no highly effective radio-protective drugs available for reducing the normal tissue damage in patients undergoing radiotherapy. One of my research goals is to evaluate an antioxidant compound to protect the normal tissue, including normal vasculature, from radiation-induced damage. This agent can be considered for translational studies to use in radiation therapy as a therapeutic radio-protector. Another research interest is to study the effect of the spaceflight condition on brain, eye and skin. I am very fortunate to be able to participate in a study to determine effects of spaceflight condition on mice that were flown in the Space Shuttle Atlantis (STS-135). Our study provides the first evidence that space flight condition induces oxidative damage that results in mitochondrial apoptosis in retina. This indicates that astronauts may be at increased risk for late retinal degeneration.