Los Angeles Biomedical Research Institute
United States of America
Dr. Ibe’s research intents to understand the role of inflammatory and anti-inflammatory proteins in pulmonary vascular injury. His work includes investigations into the role of NF-kB, intracellular kinases and retinoblastoma protein in the regulation of platelet activating factor receptor gene and protein expression. Dr. Ibe employs in vivo small, medium and large animal models and in vitro cell culture models to investigate perinatal pulmonary adaptation and the role of platelet activating factor in the pathology of persistent pulmonary hypertension of the newborn. Dr. Ibe also studies the role of these lipid mediators in cardiovascular and pulmonary abnormalities of sickle cell disease. His sickle cell disease studies are primarily focused on understanding the consequences of abnormal erythrocyte-endothelium interaction in the pathogenesis of vaso-occlusion and pulmonary hypertension in sickle cell disease.
Inflammatory and anti-inflammatory proteins in pulmonary vascular injury,role of NF-kB, intracellular kinases and retinoblastoma protein i
Platelet-activating factor synthesis and receptor-mediated signaling are downregulated in ovine newborn lungs: relevance in postnatal pulmonary adaptation and persistent pulmonary hypertension of the newborn. J Dev Orig Health Dis
Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. Mol Genet Metab
Role of platelet activating factor in pulmonary vascular remodeling associated with chronic high-altitude hypoxia in ovine fetal lambs. Am J Physiol Lung Cell Mol Physiol