Jerome I Rotter
Pediatrics, Medicine, and Human Genetics
Los Angeles Biomedical Research Institute
United States of America
Dr. Rotter is a pioneer in the field of medical genetics, genetic epidemiology, and personalized medicine. He has engaged in the study of the genetic epidemiology of chronic common diseases for over 3 decades, with an emphasis on cardiovascular/metabolic diseases (coronary artery disease, dyslipidemia, hypertension, type 2 diabetes, insulin resistance, arrhythmias), gastrointestinal/autoimmune (type 1 diabetes, Crohn’s disease, ulcerative colitis), ocular disorders (keratoconus, diabetic retinopathy, glaucoma, retinal vasculature), and pharmacogenetic studies. His studies have included family based, case control, cohort, and pharmacogenetic designs; have included different ethnic groups (Caucasian, Hispanics, African-Americans, Chinese, Ashkenazi Jews, and Armenians); and have ranged from linkage, candidate gene, genome-wide association (GWA) and post-GWA studies, and now whole exome and whole genome sequencing studies. These studies have been conducted in collaboration with clinical, physiologic, and epidemiologic investigators, often in multisite studies, such as the IRAS (Insulin Resistance and Atherosclerosis) Family Study, the CHS (Cardiovascular Health Study), the MESA (Multi-Ethnic Study of Atherosclerosis) Family Study (which for the latter he serves as PI) and the ADAGES (African Descent and Glaucoma Evaluation Study). For example, MESA/MESA Family, as studies of subclinical atherosclerosis, have assessed both coronary artery calcification and carotid intima-media thickness, and MESA serves as an observational cohort for statin response.
Genetic basis of common diseases, genome-wide association and sequencing studies.
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility - The CHARGE T2D-Glycemia Exome Consortium, Nature Communications
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes, PLOS Genetics
Macrophage class IIa HDACs link cAMP signaling to inflammation and insulin resistance, Cell Metabolism