Lou Lu
Professor
Medicine
Los Angeles Biomedical Research Institute
United States of America
Biography
The human corneal epithelial layer forms the first line of defense to protect the eye from injuries such as physical/chemical damage and/or biohazard infection. Dr. Lu’s lab focuses on investigations of significant epigenetic mechanisms concerning how corneal hypoxia in physiological and pathological conditions affect human corneal limbal stem cell differentiation and epithelial cell replacement. Additionally, his lab studies how growth factor- and environmental stress induces epigenetic responses and how they affect corneal epithelial self-renewal and wound healing. This research will provide a strong foundation for novel translational studies to treat various eye surface damages and diseases.
Research Interest
Corneal epithelial layer forms the first line of defense to protect the eye from injuries such as physical/chemical damage and/or biohazard infection.
Publications
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Osmotic Stress-induced H2AX Phosphorylation by Polo-Like-Kinase 3 in Human Corneal Epithelial Cells”. Journal of Biological Chemistry
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CCCTC-binding Factor Mediates Effect of Glucose On Beta Cell Survival”. Cell Proliferation
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Effects of NF-κB Subtype-regulated CTCF on Corneal Epithelial Wound Healing, A Transgenic Mouse Study”. Journal of Biological Chemistry,
