Nagendra N Mishra
Assistant Professor
Infectious Disease
Los Angeles Biomedical Research Institute
United States of America
Biography
Dr. Mishra's research focuses on the growing health issue of antimicrobial resistance, which threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. He has recently identified adaptations associated with lipid membranes of Candida, Staphylococci, Enterococci and Streptococci that confer resistance to certain antibiotics in vitro and in vivo. He also discovered the significance of Staphylococcal carotenoid augmented membrane fluidity/rigidity and its implications in resistance to host defense peptides and in vivo virulence in an endocarditis model. Further understanding microbial adaptation to the host in the setting of anti-infective agents aims to open new doors to anti-infective strategies addressing the current challenge of conventional antibiotic resistance.
Research Interest
antimicrobial resistance,significance of Staphylococcal carotenoid augmented membrane fluidity/rigidity,prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi.
Publications
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Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides. Antimicrob Agents Chemother. 2014
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Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides. Antimicrob Agents Chemother. 2015
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The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model. Pathog Dis. 2015
