Nestor F Gonzalez-cadavid

Biography

Dr. Nestor Gonzalez-Cadavid has spent almost two decades studying the cellular and molecular pathophysiology of erectile dysfunction (ED), Peyronie’s disease, and diabetic nephropathy, all the while exploring potential biological and pharmacological therapies for these conditions. Dr. Gonzalez-Cadavid’s research on ED was inspired by the work carried out by co-investigator, Jacob Rajfer, M.D., who, in collaboration with Nobel Prize winner Louis Ignarro, discovered that nitric oxide is the mediator of penile erection. Within this field of study, and as director of the Urology Research Laboratory, Dr. Gonzalez-Cadavid directs pioneering translational work on the concept that diffuse corporal tissue fibrosis and oxidative stress in the context of post-radical prostatectomy, aging, and diabetes are major factors for ED, similar to what occurs in a localized way, and as a result of other causes, in Peyronie’s disease. His lab work seeks to analyze stem cell therapy as a promising approach for ED that can be stimulated by concurrent pharmacological treatment. Dr. Gonzalez-Cadavid is performing translational research to, a) determine whether exposure to the environmental contaminant BPA, released from plastics and acrylics, causes ED; b) analyze and assess the therapeutic use of muscle-derived stem cells (MDSC) for ED and limb ischemia in type 2 diabetes; and, c) assess the potential cancerous effects of excessive alcohol consumption on normal or malignant stem cells.

Research Interest

Cellular and molecular pathophysiology of erectile dysfunction (ED), Peyronie’s disease, and diabetic nephropathy,