In- Residence of Obstetrics and Gynecology
Los Angeles Biomedical Research Institute
United States of America
Dr. Khorram's laboratory focuses on two areas of investigation: 1) Fetal programming of adult diseases. and 2) The role of miRNAS in the pathogenesis of uterine leiomyomas and novel medical therapies that target miRNA expression. For the past few years Dr. Khorram has investigated the mechanism by which an adverse uterine environment leads to offspring vascular remodeling and stiffness which contributes to development of hypertension in adult life. His lab has characterized the extensive vascular remodeling and showed the role of micro RNAs as novel epigenetic mechanism for programming. Ongoing studies are focused on the role of miRNA29c in regulating fetal vascular composition.
The role of miRNA29c in regulating fetal vascular composition.
Long-term effects of maternal undernutrition on offspring carotid artery remodeling: role of miR-29c.J Dev Orig Health Dis. 2015
miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids. Am J Physiol Cell Physiol. 2015
Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma. Fertil Steril. 2015