Los Angeles Biomedical Research Institute
United States of America
Renal fibrogenesis is the downstream biological process is virtually any renal disease causing renal insufficiency and, finally, complete renal failure. Dr. Hirschberg studies the pathways that contribute to fibrosis in the kidney. He found that fibroblast proliferation is regulated by TGFb pathway. A separate project in the lab examines the regulation of renal intercalated cells by TGFb and BMP.
Renal fibrogenesis,renal disease,fibroblast proliferation
Y-box protein-1 is a transcriptional regulator of BMP7. J Cell Biochem. 2011
Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol. 2006
Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. Harbor-UCLA Research and Education Institute, UCLA