Los Angeles Biomedical Research Institute
United States of America
Dr. Lee's research involves the measurement of metabolic fluxes and cellular homeostasis through metabolic regulation. In order to measure metabolic fluxes, his laboratory has developed many stable isotope techniques particularly the analysis of mass and positional isotopomers using mass spectrometry. The application of stable isotope and isotopomer analysis allows for the development of tracer-based metabolomics which measures input and output of metabolic substrates in cellular metabolism
Measurement of metabolic fluxes and cellular homeostasis through metabolic regulation.
Systems analysis of energy metabolism elucidates the affected respiratory chain complex in Leigh’s syndrome. Mol Genet Metab. 2007
Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts. Mol Genet Metab. 2002
Tracer-based metabolomics: concepts and practices. Clin Biochem. 2010