Immunology
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Alexander Y. Rudensky

Director, Ludwig Center at MSK
Ludwig Center at MSK
Ludwig Institute for Cancer Research
United States of America

Biography

In addition to directing the Ludwig Center, I am Chairman of the Immunology Program at Memorial Sloan Kettering Cancer Center and an investigator with the Howard Hughes Medical Institute. My research is focused on understanding the molecular and cellular regulatory mechanisms operating within the immune system, specifically those governing differentiation and function of regulatory T (Treg) cells. I received my PhD in 1986 from the Gabrichevsky Research Institute of Epidemiology and Microbiology in Moscow. From 1990 to 1992, during my postdoctoral training at Yale University School of Medicine with the late Dr. Charles Janeway, we provided the first description of “self” antigens associated with MHC class II molecules. In 1992 I joined the faculty of the Department of Immunology at the University of Washington, becoming a professor in the Department of Immunology. In Seattle, I led a laboratory investigating antigen presentation and T cell differentiation. I joined MSK in 2008.

Research Interest

Molecular and cellular regulatory mechanisms, immune reactions, cancer therapeutics

Publications

  • Fontenot, Jason D., et al. "A function for interleukin 2 in Foxp3-expressing regulatory T cells." Nature immunology 6.11 (2005): 1142.

  • Fontenot, Jason D., et al. "Regulatory T cell lineage specification by the forkhead transcription factor foxp3." Immunity 22.3 (2005): 329-341.

  • Fontenot, Jason D., Marc A. Gavin, and Alexander Y. Rudensky. "Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells." Nature immunology 4.4 (2003): 330-336.

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