Andrew J. Wagner
Scientist
Ludwig Center at Harvard
Ludwig Institute for Cancer Research
United States of America
Biography
Sarcomas constitute a heterogeneous family of rare tumors with mesenchymal cell origin. There are limited effective therapeutic options for patients whose disease has metastasized. Our research goals have been to create reliable laboratory models of sarcoma from patient-derived specimens, to identify novel oncogenic pathways in these tumors and to test novel targeted compounds according to the identified alterations. Correspondingly, we are studying the effects of these novel drugs in patients and analyzing tumor specimens in an effort to isolate markers of treatment sensitivity and resistance. These novel drugs specifically targeted to the genetic alteration in the tumor might provide more effective and less toxic treatment options for patients with sarcomas.
Research Interest
Tumors, therapeutics, sarcoma, novel oncogenic pathways
Publications
-
de Jonge M, de Weger VA, Dickson MA, Langenberg M, Le Cesne A, Wagner AJ, Hsu K, Zheng W, Macé S, Tuffal G, Thomas K, Schellens JH. A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours. Eur J Cancer 2017; 76:144-151.
-
Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI, Keedy VL, Singh AS, Puzanov I, Kwak EL, Wagner AJ, Von Hoff DD, Weiss GJ, Ramanathan RK, Zhang J, Habets G, Zhang Y, Burton EA, Visor G, Sanftner L, Severson P, Nguyen H, Kim MJ, Marimuthu A, Tsang G, Shellooe R, Gee C, West BL, Hirth P, Nolop K, van de Rijn M, Hsu HH, Peterfy C, Lin PS, Tong-Starksen S, Bollag G. Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med 2015; 373:428-37.
-
Nakayama R, Zhang YX, Czaplinski JT, Anatone AJ, Sicinska ET, Fletcher JA, Demetri GD, Wagner AJ. Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma. 2016.
-
Gelhorn HL, Tong S, McQuarrie K, Vernon C, Hanlon J, Maclaine G, Lenderking W, Ye X, Speck RM, Lackman RD, Bukata SV, Healey JH, Keedy VL, Anthony SP, Wagner AJ, Von Hoff DD, Singh AS, Becerra CR, Hsu HH, Lin PS, Tap WD. Patient-Reported Symptoms of Tenosynovial Giant Cell Tumors. Clin Ther 2016.
