David Scadden
Scientist
Ludwig Center at Harvard
Ludwig Institute for Cancer Research
United States of America
Biography
I am a practicing hematologist/oncologist and the Gerald and Darlene Jordan Professor of Medicine at Harvard University. My laboratory focuses on the regulation of blood-making stem cells by their microenvironment, or niche. Using a combination of genetics, imaging and pharmacology, my lab has defined key components of this niche and described how these hematopoietic stem cells reach and settle down in the bone marrow. We have demonstrated the primary role the microenvironment can play in the emergence of malignancy. We have also shown how such niche interactions can be manipulated and altered, studies that have resulted in two clinical trials in the use of stem cells to treat blood cancers. I am particularly interested in applying my laboratory work to the treatment of cancer and am the founding Director of the Center for Regenerative Medicine at the Massachusetts General Hospital, I also co-founded and Co-Direct the Harvard Stem Cell Institute and the Harvard University Department of Stem Cell and Regenerative Biology. I am a Member of the Institute of Medicine of the National Academies of Science, the Board of External Experts for the National Heart, Lung and Blood Institute and a former member of the National Cancer Institute’s Board of Scientific Counselors. I am the recipient of multiple honorary degrees, awards and memberships in honorary societies.
Research Interest
Hematology, oncology, stem cells
Publications
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Papazian, Ani E., Youmna S. Kfoury, and David T. Scadden. "Shipping mouse bone marrow: Keep it in the bone." Experimental hematology 49 (2017): 68-72.
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Vionnie, W. C., et al. "Epigenetic memory underlies cell-autonomous heterogeneous behavior of hematopoietic stem cells." Cell 167.5 (2016): 1310-1322.
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Kalaitzidis, Demetrios, et al. "Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells." The Journal of clinical investigation 127.4 (2017): 1405-1413.
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Baryawno, Ninib, Nicolas Severe, and David T. Scadden. "Hematopoiesis: Reconciling Historic Controversies about the Niche." Cell Stem Cell 20.5 (2017): 590-592.
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Lee, Pui Y., et al. "The metabolic regulator mTORC1 controls terminal myeloid differentiation." Science Immunology 2.11 (2017): eaam6641.
