Jean-philippe Defour
Scientist
Ludwig Center at Brussels
Ludwig Institute for Cancer Research
United States of America
Biography
BCR-ABL1 negative myeloproliferative neoplasms include Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis. Type-1 homodimeric receptors (such as TpoR or c-Mpl) play a central role in the ontogenesis of those diseases. I am working on a structural project that aims to elucidate the structure of the transmembrane and cytosolic domains of TpoR, and where we identified novel oncogenic mutants of TpoR. Furthermore, I am responsible for cytology at St. Luc Hospital, and I study signaling in primary samples from patients with myeloid cancers.
Research Interest
Neoplasms, signalling, cancer
Publications
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Cabagnols, Xenia, et al. "Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution." Leukemia 29.1 (2015): 249.
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Cabagnols, Xénia, et al. "Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients." Blood 127.3 (2016): 333-342.
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Chachoua, Ilyas, et al. "Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants." Blood (2015): blood-2015.
