Nathalie Vigneron
Scientist
Ludwig Center at Brussels
Ludwig Institute for Cancer Research
United States of America
Biography
As a post-doctoral researcher in the laboratory of tumor immunology and antigen processing, my work mostly focuses on understanding the parameters involved in the production of antigenic peptides recognized by cytolytic T lymphocytes on tumors, to define which peptides are best suited for the development of anti-cancer vaccine. My main interest lies in the role of proteasome, which is the main complex responsible for the release of antigenic peptides from the degradation of intracellular proteins. Additionally, I study the importance of TAP and tapasin in the processing of antigenic peptides as these two proteins often down-regulated in tumors.
Research Interest
Tumor immunology, anti-cancer vaccine, proteasome
Publications
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Warren, Edus H., et al. "An antigen produced by splicing of noncontiguous peptides in the reverse order." Science 313.5792 (2006): 1444-1447.
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Vigneron, Nathalie, et al. "An antigenic peptide produced by peptide splicing in the proteasome." Science 304.5670 (2004): 587-590.
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Germeau, Catherine, et al. "High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens." Journal of Experimental Medicine 201.2 (2005): 241-248.
