Rakesh Jain
Scientist
Ludwig Center at Harvard
Ludwig Institute for Cancer Research
United States of America
Biography
The overarching goal of my research is to dissect the pathophysiology of the vascular and extra-vascular components of tumors, to determine the role of tumor-host interactions in tumor biology and, ultimately, to translate this knowledge into improved cancer detection, prevention and treatment in humans. To unravel the complex biology of tumors, my laboratory has developed an array of imaging technologies, mathematical models and sophisticated animal preparations. Our work has provided unprecedented molecular, cellular, anatomical and functional insights into the vascular, interstitial and cellular barriers to cancer treatment. It has also led to more than 25 clinical trials for various cancers and the development of new approaches to cancer therapy. I received my Ph.D. in chemical engineering from the University of Delaware and am today A. W. Cook Professor of Radiation Oncology (Tumor Biology) at Harvard Medical School and Director of the Edwin L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital. I have received numerous honors for my research, including the 2013 National Medal of Science, awarded in 2016. I am a fellow of the National Academy of Medicine, the National Academy of Engineering, the American Academy of Arts and Sciences and the National Academy of Sciences.
Research Interest
Tumors, tumor-host interactions, cancer detection, prevention and treatment
Publications
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De Palma, Michele, and Rakesh K. Jain. "CD4+ T cell activation and vascular normalization: Two sides of the same coin?." Immunity 46.5 (2017): 773-775.
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Liu, Hao, et al. "Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma." Clinical Cancer Research (2017): clincanres-0256.
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Askoxylakis, Vasileios, et al. "Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?." Breast cancer research and treatment 165.2 (2017): 467.
