Ludwig Center at MSK
Ludwig Institute for Cancer Research
United States of America
I developed a three-dimensional collagen-fibrin gel system to examine tumor-specific T cell killing. Coupled with an equation (bt=b0e-kpt+gt) that accurately models T cell killing of melanoma cells, collagen-fibrin gels represent a quantitative model for assessing the cytolytic activity of antigen-specific T cells. My research focuses on quantitatively assessing the role of radiation, chemotherapy, immune modulation and cancer-specific vaccines on the effector T cell responses to tumor antigens using breast cancer and melanoma as model systems.
Melanoma, radiation, chemotherapy, immune system models
Loike, John D., et al. "Differential regulation of β1 integrins by chemoattractants regulates neutrophil migration through fibrin." The Journal of cell biology 144.5 (1999): 1047-1056.
Hirschhorn-Cymerman, Daniel, et al. "Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype." Journal of Experimental Medicine (2012): jem-20120532.
Budhu, Sadna, et al. "CD8+ T cell concentration determines their efficiency in killing cognate antigen–expressing syngeneic mammalian cells in vitro and in mouse tissues." Journal of Experimental Medicine (2010): jem-20091279.