Stefania Cane
Scientist
Ludwig Center at Brussels
Ludwig Institute for Cancer Research
United States of America
Biography
I am seeking to identity and understand the mechanisms of the local immunosuppression and extracellular matrix remodeling in a mouse model of inducible melanoma, referred as TirRP-10B;Ink4a/Arfflox/flox;H-2d/d, which recapitulates the natural interaction and cross-talk between the tumor, the stroma and the immune system. Preliminary gene expression analysis revealed a clear TGFβ signature occurring in the most aggressive form of tumor (not-pigmented) as compared to the less aggressive (pigmented) form. Thus, employing newly generated TGFβ neutralizing antibodies we would like to understand whether TGFβ neutralization retards/prevents EMT-like dedifferentiation and thereby reduces tumor progression.
Research Interest
Immunity,cancer
Publications
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Vigneron, Nathalie, et al. "Database of T cell-defined human tumor antigens: the 2013 update." Cancer Immunity Archive 13.3 (2013): 15.
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Vigneron, Nathalie, et al. "An antigenic peptide produced by peptide splicing in the proteasome." Science 304.5670 (2004): 587-590.
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Germeau, Catherine, et al. "High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens." Journal of Experimental Medicine 201.2 (2005): 241-248.
