Gary O. Rankin

Biography

I was Chair of the Department of Pharmacology from 1986-2005, and when my department was merged with the Department of Physiology, I was made Chair of the combined department, a position I still hold. Over the years, I have mentored numerous undergraduate (26), graduate (40) and medical students (18), postdoctoral fellows (7) and faculty members, both within and outside my department and institution. In addition, I am the principal investigator of the NIH-funded West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE). In this capacity, I oversee a state-wide network composed primarily of new investigators at primarily undergraduate institutions across West Virginia, and serve as mentor for several of them. I have also served as a mentor for COBRE investigators at Marshall University and reviewed COBRE and other IDeA applications for NIH. Thus, I have over 30 years of experience as a mentor in many different capacities. It is also worth noting that my laboratory has been involved in translational research. One of our recent projects involves examining the pharmacogenetics of humans who died from methadone overdose. Working with medical examiner’s offices in West Virginia and Kentucky, we have obtained DNA from autopsy blood cards and are examining single nucleotide polymorphisms (SNPs) in cytochrome P450s (CYPs) related to methadone metabolism as a possible explanation for the overdose deaths and as a predictive tool for preventing methadone overdose in patients taking the drug for addiction treatment or cancer pain. We are also collaborating with Dr. Monica Valentovic, Marshall University, on a project to find adjunctive treatments to prevent cisplatin nephrotoxicity and with Dr. Yi Chen, Alderson Broaddus University, to find natural products that can be used in the treatment of ovarian cancer. Lastly, as part of our work in the field of nephrotoxicity, we have examined the role of renal transporters in the accumulation of the toxicants we are studying

Research Interest

Halogenated anilines, Methadone, nephrotoxicity