Isabel Larre
Assistant Professor
Department of Clinical and Translational Science
Marshall University
United States of America
Biography
My research includes the regulation of the function and the molecular composition of tight junctions by the Na/K-ATPase ligand ouabain, which is the foundation of this proposed research. In addition, I have had numerous fruitful collaborations with other researchers in the field of gap junctions. These accomplishments demonstrate my ability to participate in productive-collaborative teams requiring frequent communication among project members to define realistic research goals and to publish papers. I was invited to write book chapters detailing techniques for studying tight junction. As a junior investigator at MIIR and in Marshall University School of Medicine, my interest is to study how sodium pump regulates epithelial phenotype.
Research Interest
Regulation of the function and the molecular composition of tight junctions by the Na/K-ATPase ligand ouabain
Publications
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The Na+-K+-ATPase as self-adhesion molecule and hormone receptor. Cereijido M, Contreras RG, Shoshani L, Larre I. Am J Physiol Cell Physiol. 2012;302(3):C473-81. 3.
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Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2- dependent pathways. Rincon-Heredia R, Flores-Benitez D, Flores-Maldonado C, BonillaDelgado J, GarcÃa-Hernández V, Verdejo-Torres O, Castillo AM, Larré I, Poot-Hernández AC, Franco M, Gariglio P, Reyes JL, Contreras RG. Exp Cell Res. 2013.
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The emergence of the concept of tight junctions and physiological regulation by ouabain. Larre I, Ponce A, Franco M, Cereijido M. Semin Cell Dev Biol
