Department of Biomedical Sciences
United States of America
Studies in my laboratory examine how components of tobacco can promote the progression of lung cancer. Nicotine is the major active and addictive component of cigarette smoke. Our research focuses on how nicotine can facilitate the growth and progression of lung cancers. Although nicotine is not a carcinogen, my studies indicate that it can induce proliferation, angiogenesis and metastasis of lung cancers. Additionally, it can also protect lung cancer cells against chemotherapeutic drug-induced apoptosis. These actions of nicotine are mediated by high affinity nicotinic acetylcholine receptors on lung cancer cells. My lab tries to decipher the signaling pathways by which nicotine promotes the growth and survival of lung tumors. On a more basic level, we try to analyze the physiological function of these neuronal receptors in the lung.
Nicotine can facilitate the growth and progression of lung cancers.
Pillai, S., Dasgupta, P., Chellappan, S.P. (2009) Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. In: CHROMATIN PROTOCOLS Ed. SP Chellappan, Methods Mol. Biol., 523, 323-329. Humana Press Inc., NJ, USA.
Lau, J. K., Brown, K.C., Dom, A.M. and Dasgupta, P. (2012) Capsaicin: Potential Applications in Cancer Therapy. In: NUTRITION AND CANCER, Ed. P.P. Claudio and R.M. Niles, 15-25, Bentham Press Inc., London, United Kingdom.
Pillai, S., Dasgupta, P. and Chellappan S.P. (2015) Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo. Methods Mol. Biol. 1288, 4129-4146.