Sandrine V. Pierre
Associate Investigator & Education Coordinator
Department of Biomedical Sciences
Marshall University
United States of America
Biography
My major research interest is centered on two fundamental questions surrounding the ubiquitously expressed protein Na+,K+-ATPase: the physiological role of the Na+,K+-ATPase structural heterogeneity, and the Na+,K+-ATPase signaling function. Specifically, my laboratory’s main goal is to further characterize these new aspects of Na+,K+-ATPase structure and function and explore new ways of protecting the ischemic myocardium using the cardiac Na+,K+-ATPase as a target for therapeutic intervention. Live recording of aortic and ventricular pressures during ischemia and reperfusion in an ex-vivo mouse heart preparation (Langendorff). We examine these issues by combining techniques of molecular and cell biology with ex-vivo (biochemistry and cell physiology, isolated heart perfusion, primary cardiac cell cultures, histology) and in-vivo assessments of cardiac function (echocardiography, tail-cuff measurement of blood pressure, cardiac catheterization) in genetically altered mice.
Research Interest
The physiological role of the Na+,K+-ATPase structural heterogeneity, and the Na+,K+-ATPase signaling function
Publications
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Costa, A.D., Pierre, S.V., Cohen, M.V., Downey, J.M. and Garlid, K.D. cGMP signaling in pre- and post-conditioning: the role of mitochondria. Cardiovasc. Res. 2008; 77: 344-352.
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Pasdois, P., Quinlan, C.L., Rissa, A., Tariosse, L., Vinassa, B., Pierre, S.V., Dos Santos, P., and Garlid, K.D. Ouabain protects rat hearts against ischemia-reperfusion injury via a pathway involving Src kinase, mitoKATP, and ROS. Am. J. Physiol. Heart Circ. Physiol. 2007; 292: H1470-H1478.
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Pierre, S.V., Yang, C., Yuan, Z., Seminerio, J., Mouas, K., Dos Santos, P., and Xie, Z.J. Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts. Cardiovasc Res. 2007; 73: 488-96.
