Michigan Technological University
United States of America
Our research interests are in the area of organic synthesis, which include the synthesis of natural and unnatural useful molecules and development of synthetic methodologies. Recently, we have developed a new class of chiral ligands based on two common ferrocenyl motifs. These ligands are expected to be useful in asymmetric catalysis to control the stereochemistry of a wide range of organic transformations. Another contribution we made recently is the development of two new methods for synthetic oligonucleotide purification. Due to the use of an innovative catching by polymerization approach, these methods are suitable for large scale purification of oligonucleotide drugs.
Organic synthesis, including the synthesis of natural and unnatural useful molecules and the development of synthetic methodologies.
Xiang Zhang, Rudy L. Luck, Shiyue Fang. Ferrosalen and Ferrosalen-type Ligands: Structural Modulation and Applications in Asymmetric Catalysis. Organometallics 2011, 30, 2609-2616.
Yinan Yuan, Suntara Fueangfung, Xi Lin, Durga Pokharel, Shiyue Fang. Synthetic 5′-Phosphorylated Oligodeoxynucleotide Purification through Catching Full-length Sequences by Polymerization. RSC Advances 2012, 2, 2803-2808.
(Invited publication) Shiyue Fang, Suntara Fueangfung, Yinan Yuan. Purification of Synthetic Oligonucleotides via Catching by Polymerization. In Current Protocols in Nucleic Acid Chemistry (Martin Egli, Piet Herdewijn, Akira Matusda, Yogesh S. Sanghvi, eds.). John Wiley and Sons, New York, 2012, Unit 10.14.1-10.14.21.