Ajay P. Singh
Professor
Oncologic Sciences
Mitchell Cancer Institute
United States of America
Biography
Dr. Ajay Singh is a tenured Professor of Oncologic Sciences. He also leads a multi-disciplinary research program in Cancer Health Disparities. His laboratory primarily focuses on the molecular mechanisms involved in cancer progression and chemoresistance, and development of novel mechanism-based approaches for cancer therapy and prevention. He received his Ph.D. in Life Science from Devi Ahilya University, India, and postdoctoral training in Cancer Biology at UNMC/Eppley Cancer Institute, Omaha, Neb. He has received numerous honors and awards, both in India and the U.S., for his scientific accomplishments. Research programs in his laboratory have been supported through funding from NIH/NCI, DOD, and Nebraska and Alabama’s health departments. He also serves as a Co-PI on a NSF-MRI project that established TEM core facility at the University to benefit ongoing research programs and training of next-generation biomedical engineers and research professionals. Dr. Singh actively serves on DOD and NIH study sections, and has been on the review panel boards of other national and international funding agencies, and private foundations that provide support for cancer research.
Research Interest
Cancer progression and metastasis, Therapeutic resistance in cancer, Tumor-stromal interactions, Molecular bases of cancer health disparities, MicroRNAs in cancer, Molecular diagnosis, prognosis and sub-classification of cancer, Natural products as cancer prevention and therapy agents
Publications
-
Chaturvedi P, Singh AP, Batra SK. Structure, evolution, and biology of the MUC4 mucin. The FASEB Journal. 2008 Apr 1;22(4):966-81.
-
Chaturvedi P, Singh AP, Moniaux N, Senapati S, Chakraborty S, Meza JL, Batra SK. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Molecular cancer research. 2007 Apr 1;5(4):309-20.
-
Duarte S, Gregoire S, Singh AP, Vorsa N, Schaich K, Bowen WH, Koo H. Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms. FEMS Microbiology Letters. 2006 Feb 15;257(1):50-6.
-
Singh AP, Moniaux N, Chauhan SC, Meza JL, Batra SK. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer research. 2004 Jan 15;64(2):622-30.
