Kerry J. Murphy
Assistant Professor
Department of Medicine
Montefiore Medical Center
United States of America
Biography
My clinical translational research is focused on the impact of reproductive hormones, both endogenous and exogenous on genital tract mucosal immunity and the vaginal microbiome in HIV-infected and at risk women. The goal of this work is to identify the biologic mechanisms that mediate changes in genital tract immunity and the vaginal microbiome in the setting of high progesterone states e.g. progesterone-dominant hormonal contraceptives and low estrogen states e.g. menopause as these states represent periods of vulnerability for HIV acquisition and transmission. The long-term goal of this research is to develop targeted interventions to augment these hormonally responsive changes in the genital tract in order improve genital tract health and HIV prevention.
Research Interest
HIV-infected and at risk women
Publications
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Murphy K, Richardson BA, Dezzutti CS, Marrazzo J, Hillier SL, Hendrix CW, Herold, BC. Levels of Genital Tract Defensins and Cytokines Differ between HIV-Uninfected US and African Women. Am J Reprod Immunol 2015; 74(4):313-22.
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Murphy K, Mitchell CM. The Interplay of Host Immunity, Environment on Risk of Bacterial Vaginosis and Associated Reproductive Health Outcomes. J Infect Dis 2016; Aug 15;214 Suppl 1:S29-35.
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Scherzer R, Greenblatt RM, Merhi ZO, Kassaye S, Lambert-Messerlian G, Maki PM, Murphy K, Karim R, Bacchetti P. Use of antimullerian hormone to predict the menopausal transition in HIV-infected women. Am J Obstet Gynecol 2017;216:46.e1-11.
