Zeruth, Gary T

Biography

His lab is broadly interested in understanding how transcription factor networks control development and physiology and characterizing how mutations in transcription factors give rise to disease. Using the zebrafish as a model organism, we hope to 1) understand how endocrine lineages are specified in the pancreas, 2) to characterize the signals that regulate β cell mass both neonatally and in response to nutrient excess, and 3) to delineate the molecular events that result in β cell dysfunction preceding type 2 diabetes. Additionally, we are using zebrafish along with in vitro techniques to 4) determine the role a tiny, hair-like organelle called the primary cilium plays in regulating blood glucose homeostasis.

Research Interest

physiology genetics